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HCB-811 Cancer Genetics
Campus
ASAB
Programs
PG
Session
Fall Semester 2016
Course Title
Cancer Genetics
Course Code
HCB-811
Credit Hours
3-0
Pre-Requisutes
Course Objectives
The course objective is to introduce the students to important and current concepts in Cancer Biology and Cancer Genetics. The main focus of the course is to introduce students about genetic and molecular basis of cancers, their causative agents and malignant transformation of cancer cells.
Detail Content
Introduction
Essential Alterations for malignant transformation
Onco-genes, Proto-onco-genes and Onco-proteins
Proto-oncogene
Viral oncogene and RNA tumor virus
v-oncvs c-onc
DNA tumor virus
Tumor Suppression Genes
Discovery of the first Tumor suppressor gene
The RB and p53 genes
Loss of function of the RB protein
The p53 gene
Other Tumor suppressor genes
Development of sustained angiogenesis
Tumor progression
Precancerous stage
The noninvasive stage
Invasion and dissemination
Metastasis
Invasion of extracellular matrix
Molecular genetics of metastasis development
Dysregulation of cancer and its associated genes
Growth factors and their receptors
Non-receptor tyrosine kinases
Nuclear signaling
Trancommentional activation
Mechanisms of Oncogene activation
Carcinogens and oncogene activation
Oncogene cooperation
Normal cells suppress tumor growth
Angiogenesis and tumor development
Tumor Suppressor genes
The Rb locus
p53 suppressor gene
Other tumor suppressors
Apoptosis and its role in growth regulation
Senescence
Chromosomal changes
Gene amplification
Epigentic changes
Molecular profiles of cancer cells
Cancer-causing agents
Oncogenic viruses
DNA viruses
Human papillomaviruses
Epstein-Barr virus
Hepatitis B virus
RNA viruses
Chemicals
Initiators
Promoters
Radiation
Ultraviolet radiation
Ionizing radiation
Text/Ref Books
The Biological Basis of Cancer by Robert G. McKinnell, Ralph E. Parchment, Alan O. Perantoni, G. Barry Pierce, Ivan Damjanov
Molecular Biology of the cell by Alberts et al. 2005
The Biology of CancerbyRobert A. Weinberg
Time Schedule
Fall Semester 2014
Faculty/Resource Person
Dr. HajraSadia
PhD (NIBGE, Faisalabad, Pakistan)
Discipline: Biotechnology
Specialization: Cancer Biology