National University of Sciences and Technology
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HCB-811 Cancer Genetics
Campus ASAB
Programs PG
Session Fall Semester 2016
Course Title Cancer Genetics
Course Code HCB-811
Credit Hours 3-0
Course Objectives The course objective is to introduce the students to important and current concepts in Cancer Biology and Cancer Genetics. The main focus of the course is to introduce students about genetic and molecular basis of cancers, their causative agents and malignant transformation of cancer cells.
Detail Content
  • Introduction
  • Essential Alterations for malignant transformation
  • Onco-genes, Proto-onco-genes and Onco-proteins
  • Proto-oncogene
    • Viral oncogene and RNA tumor virus
    • v-oncvs c-onc 
    • DNA tumor virus
  • Tumor Suppression Genes
    • Discovery of the first Tumor suppressor gene
    • The RB and p53 genes
      • Loss of function of the RB protein
      • The p53 gene
    • Other Tumor suppressor genes
  • Development of sustained angiogenesis
  • Tumor progression
    • Precancerous stage
    • The noninvasive stage
    • Invasion and dissemination
  • Metastasis
  • Invasion of extracellular matrix
  • Molecular genetics of metastasis development
  • Dysregulation of cancer and its associated genes
  • Growth factors and their receptors
  • Non-receptor tyrosine kinases    
  • Nuclear signaling
  • Trancommentional activation
  • Mechanisms of Oncogene activation   
  • Carcinogens and oncogene activation
  • Oncogene cooperation
  • Normal cells suppress tumor growth 
  • Angiogenesis and tumor development
  • Tumor Suppressor genes
    • The Rb locus   
    • p53 suppressor gene       
    • Other tumor suppressors
      • Apoptosis and its role in growth regulation
    • Senescence
  • Chromosomal changes
    • Gene amplification 
    • Epigentic changes
  • Molecular profiles of cancer cells
  • Cancer-causing agents
    • Oncogenic viruses
      • DNA viruses
      • Human papillomaviruses
      • Epstein-Barr virus
      • Hepatitis B virus
      • RNA viruses
    • Chemicals
      • Initiators
      • Promoters
    • Radiation
      • Ultraviolet radiation
      • Ionizing radiation
Text/Ref Books
  1. The Biological Basis of Cancer by Robert G. McKinnell, Ralph E. Parchment, Alan O. Perantoni, G. Barry Pierce, Ivan Damjanov
  2. Molecular Biology of the cell by Alberts et al. 2005
  3. The Biology of CancerbyRobert A. Weinberg
Time Schedule Fall Semester 2014
Faculty/Resource Person Dr. HajraSadia
PhD (NIBGE, Faisalabad, Pakistan)
Discipline: Biotechnology
Specialization: Cancer Biology