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HCB-911 DNA Damage and Repair
Campus
ASAB
Programs
PG
Session
Fall Semester 2016
Course Title
DNA Damage and Repair
Course Code
HCB-911
Credit Hours
3-0
Pre-Requisutes
Course Objectives
DNA damage checkpoint and repair genes are important suppressors of cancer and aging. These processes function as part of a complex interconnected network of DNA recognition and processing, checkpoint signaling cascades and DNA repair. Because these processes preserve genome integrity, how they cooperate with one another is strongly related to their ability to suppress cancer and aging. This particular course is designed to study this emerging research area and to give the students an advanced understanding of DNA damage checkpoints, DNA repair and the connections of these processes with cancer and aging.
Detail Content
Introduction to DNA Replication, Repair, and Recombination
The Maintenance of DNA Sequences
DNA Replication mechanisms
Initiation and completion of DNA replication
DNA replication and cell cycle
Fidelity of DNA Replication
DNA Damage
Damage due to alkylation
Damage due to the incorporation of base analogues
Damage due to deamination and
Role of DNA glycosylases in deamination,
Types of DNA glycosylases
Damage due to the formation of pyrimidine dimmers and role of photolyase
Damage due to oxidation
DNA Repair
Types of DNA Repair
Direct Repair or reversal system
Excision Repair
Molecular mechanism of nucleotide excision repair
Nucleotide Excision Repair
Mismatch Repair and mutator genes
Double strand break (DSB) repair system
Genes involved in DSB
Homologous recombinational Repair Systems
Non Homologous recombinational Repair Systems
SOS Repair system
Inducible Repair system
Machineries for chromosomal DNA repair
Repair of DNA double-strand breaks within chromatin
Chromatin-modifying and remodeling enzymes
Histone phosphorylation is a marker for DSB repair
Histone acetylation and DSB repair
Structural insights into the DNA damage response
Defective DNA damage responses and cancer
Cancer treatment based on knowledge about the DNA damage response – targeted therapeutics
Cancer treatment based on specific mutations that "drive" malignant growth – exploiting oncogene addiction
Text/Ref Books
Cell Cycle and Growth Control: Biomolecular Regulation and Cancer byGary S. Stein, Arthur B. Pardee.
DNA Damage Recognition by Wolfram Siede and Paul W. Doetsch.
DNA Repair and Mutagenesis by Errol C. Friedberg.
DNA Damage Repair: Repair Mechanisms and Aging byThomas, Allison E.
Advances in DNA Damage and Repair by MiralDizdaroglu and Ali EsatKarakaya.
Scientific Journal: DNA Repair by Elsevier.
Time Schedule
Fall Semester 2014
Faculty/Resource Person
Dr. Nasir Jalal
PhD (Colorado State University, USA)
Discipline: Cell and Molecular Biology