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HCB-912 Molecular Virology
Campus ASAB
Programs PG
Session Fall Semester 2016
Course Title Molecular Virology
Course Code HCB-912
Credit Hours 3-0
Course Objectives This 3 credit course, "Molecular Virology" is being designed to introduce students the fundamentals of virology with an emphasis on the molecular aspects of viral replication, pathogenesis, and host interactions. The major objective of the course is to provide students with an integrated and fundamental understanding of how viruses with different genomes replicate. Because of the contents, this course will be very helpful as prerequisites for VIRO-204 (Viral vectors) and subsequent virology courses.
Detail Content
  • Introduction to viruses
  • Positive-sense RNA viruses
  • RNA-directed RNA replication
  • Positive-sense RNA viruses encoding a single large open reading frame
    • Picornavirus replication
    • The poliovirus protein expression
  • Flavivirus replication
  • Positive-sense RNA viruses encoding more than one translational reading frame
    • Togavirus genome
    • Coronavirus replication
    • Replication strategies of RNA Viruses requiring RNA-directed mRNA trancommention
    • Rhabdoviruses (Viruses with monopartite genome)
    • Influenza viruses (Viruses with multipartite genome)
    • Ambisense RNA viruses
    • Replication strategies of small and medium sized DNA viruses
  • Papovavirus replication
  • Replication of SV40 virus – the model polyomavirus
  • Adenovirus genome
  • Geminiviruses
  • Retroviruses-converting RNA to DNA
  • The molecular biology of retrovirus
  • Retrovirus structural proteins
  • The retrovirus genome
  • Replication of retroviruses: an outline of the replication process
  • Initiation of infection
  • Capsid assembly and maturation
  • Action of reverse trancommentase and RNase-H in synthesis of cDNA
  • Virus gene expression, assembly, and maturation
  • Trancommention and translation of viral mRNA
  • Capsid assembly and morphogenesis
  • Retrotransposons
  • Lentiviruses- HIV-1
  • Replication of nuclear-replicating DNA viruses
  • Herpesvirus replication
  • HSV virion and viral genome
  • Baculoviruses
  • Replication of cytoplasmic DNA viruses
  • Poxviruses replication cycle
Text/Ref Books
  1. Introduction to Modern Virology by N.J.Dimmock, A.J.Easton, and K.N.Leppard.
  2. Basic Virology by Edward Karl Wagner
  3. Fundamental Virology by David M Knipe and Peter M Howley
  4. Principals of virology by Alan J. Cann.
  5. Virology: Principles and Applications by John Carter and Venetia Saunders
  6. Virology by Carter (2007)
Time Schedule Fall Semester 2014
Faculty/Resource Person Dr. SobiaManzoor
PhD (CEMB University of the Punjab Lahore)

Discipline: Molecular Virology