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HCB-912 Molecular Virology
Campus
ASAB
Programs
PG
Session
Fall Semester 2016
Course Title
Molecular Virology
Course Code
HCB-912
Credit Hours
3-0
Pre-Requisutes
Course Objectives
This 3 credit course, "Molecular Virology" is being designed to introduce students the fundamentals of virology with an emphasis on the molecular aspects of viral replication, pathogenesis, and host interactions. The major objective of the course is to provide students with an integrated and fundamental understanding of how viruses with different genomes replicate. Because of the contents, this course will be very helpful as prerequisites for VIRO-204 (Viral vectors) and subsequent virology courses.
Detail Content
Introduction to viruses
Positive-sense RNA viruses
RNA-directed RNA replication
Positive-sense RNA viruses encoding a single large open reading frame
Picornavirus replication
The poliovirus protein expression
Flavivirus replication
Positive-sense RNA viruses encoding more than one translational reading frame
Togavirus genome
Coronavirus replication
Replication strategies of RNA Viruses requiring RNA-directed mRNA trancommention
Rhabdoviruses (Viruses with monopartite genome)
Influenza viruses (Viruses with multipartite genome)
Ambisense RNA viruses
Replication strategies of small and medium sized DNA viruses
Papovavirus replication
Replication of SV40 virus – the model polyomavirus
Adenovirus genome
Geminiviruses
Retroviruses-converting RNA to DNA
The molecular biology of retrovirus
Retrovirus structural proteins
The retrovirus genome
Replication of retroviruses: an outline of the replication process
Initiation of infection
Capsid assembly and maturation
Action of reverse trancommentase and RNase-H in synthesis of cDNA
Virus gene expression, assembly, and maturation
Trancommention and translation of viral mRNA
Capsid assembly and morphogenesis
Retrotransposons
Lentiviruses- HIV-1
Replication of nuclear-replicating DNA viruses
Herpesvirus replication
HSV virion and viral genome
Baculoviruses
Replication of cytoplasmic DNA viruses
Poxviruses replication cycle
Text/Ref Books
Introduction to Modern Virology by N.J.Dimmock, A.J.Easton, and K.N.Leppard.
Basic Virology by Edward Karl Wagner
Fundamental Virology by David M Knipe and Peter M Howley
Principals of virology by Alan J. Cann.
Virology: Principles and Applications by John Carter and Venetia Saunders
Virology by Carter (2007)
Time Schedule
Fall Semester 2014
Faculty/Resource Person
Dr. SobiaManzoor
PhD (CEMB University of the Punjab Lahore)
Discipline: Molecular Virology