National University of Sciences and Technology
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BMES 824 Biosensors and Instrumentation
Campus SMME
Programs PG
Session Summer Semester 2016
Course Title Biosensors and Instrumentation
Course Code BMES 824
Credit Hours 3-0
Pre-Requisutes
Course Objectives The Biosensors and Instrumentation module examines the methods used to interface sensors for biological and biomedical applications with electronics. One focus will be on transducers, meaning devices which convert information from one form of energy to another. In this case the final form for the information will be an electrical signal but the transducers themselves could be optical, mechanical, etc., and operate in a number of different ways (e.g., capacitive, potentiometric, photonic). The objective is to build upon the knowledge the students will have gained in the first semester courses on biosensors and bioelectronics but with more of an electronics and electrical engineering focus. This course will also go beyond sensing to look at methods of actuation for closed loop smart systems. Examples from the state of the art in biosensor research will be provided and a number of guest lectures from active researchers in this field will provide context. Students will undertake a horizon scanning research exercise to investigate the industrial and research potential of a specific type of biosensor. This will be assessed by both formal reports and a presentation given to and marked by the whole class.
Detail Content
  • Transducer Basics: Sensors and Actuators, definitions, types of sensors, target analytes, various recognition, signals, and device types.
  • Sensor calibration, dynamic Range, signal to noise,  sensitivity, selectivity, interference
  • Sensor Amplification: Op-amps, basic circuits Instrumentation for Electrochemistry: Potentiostats, impedance measurements, bridge circuits
  • Glucose biosensors
  • Enzyme sensors
  • Membrane protein sensors: ion channels, receptors
  • Whole cell sensors
  • Temperature measurements Mechanical sensor instrumentation: Strain gauges, piezoelectric sensors and actuators, capacitive sensor interfaces
  • FET based sensors: MOSFET revision, FET based biosensors, nano-wire sensors.
  • Optical biosensors: Fibre-optic sensors, fluorescence
  • Neural sensors and actuators: Microelectrode arrays, neural implants
  • Implantable medical devices: Biofouling, materials and regulation
  • Wireless sensor interfaces: Sensor networks and wireless power
The coursework will also be included assignments on functional demonstration of different sensors.
Text/Ref Books
  • Instrumental Methods in Electrochemistry, Southampton Electrochemistry Group, Ellis Horwood or Halsted Press.
  • Medical Instrumentation: Application and Design John G. Webster, Wiley, (4th Edition) Ultra Low Power Capacitive Sensor Interface W. Bracke, R. Puers& C. Van Hoof; Springer.
  • Biomedical Instruments - Theory and Desig W. Welkowitz, S. Deutsch, M. Akay; Academic Press Inc. 
  • Ultra Low Power Bioelectronics R. Sarpeshkar; Cambridge University Press.
Time Schedule Summer Semester 2014
Faculty/Resource Person Dr. Nosheen Fatima PhD (France)
Discipline: Biomedical Sciences
Specialization: Biochemistry and Biogenetics
and
Dr. Omer Gilani PhD (Singapore)
Discipline: Biomedical Engineering
Specialization: Bioinstrumentation and Vision systems