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HCB-817 Cancer Biology
Campus
ASAB
Programs
PG
Session
Fall Semester 2016
Course Title
Cancer Biology
Course Code
HCB-817
Credit Hours
3
Pre-Requisutes
None
Course Objectives
Understand cancer statistics and the decommentive epidemiology of cancer;
Understand known risk factors and gaps in knowledge for the major cancers;
Understand the biology of cancer;
Apply methods in the design, conduct, and analysis of cancer research studies;
Apply critical thinking in the review of projects and publications in cancer biology;
Appreciate the multidisciplinary aspect of cancer including the contributions of basic sciences, clinical medicine and the social sciences to the understanding of cancer biolgy and progression.
Detail Content
History &Introduction
History of Cancer Detection
Stages of Tumor Progression
Initiators and Promoters
Carcinogens
Carcinogens Cancer Causing Substances
List of Carcinogens and the Cancers They Cause
Environmental Agents and Cancer Development
Viruses aand Bacteria that Cause Cancer
Chronic Inflammation and Cancer Development
The Two-Stage Model of Cancer Development
Cancer Initiation, Promotion and Progression
What are Cancer Stem Cells
An Introduction to Cancer Treatments
Cancer Stem Cells and Treatment
Introduction to Cancer Prevention
Cancer Detection and Diagnosis
Introduction to Cancer by Type
Introduction to How Cancer Spreads
Introduction to Characteristics of Cancer Cells
Changes in Physical Properties of Cancer Cells
1Growth without 'GO' Signals
Failure to Respond to 'STOP' Signals
Unlimited Number of Cell Divisions
Avoidance of Cell Death
Angiogenesis
Introduction to Metastasis
Formation of Metastases
Routes of Metastasis
Spread of Cancer through the Lymphatic System
The Lymphatic System
Organ Targeting Anatomic vs Seed & Soil Models
The Anatomic Model
The Seed and Soil Hypothesis
How Metastases Form New Tumors (Colony Formation)
Obstacles to Colony Formation
Barriers to Metastasis
Barriers to Metastatic Cancer Cell Growth
Treatments that Target Metastasis (Metastatic Suppressors)
Anti-angiogenesis Therapy
Introduction to the Tumor-Host Interactions
Overview of the Tumor Microenvironment
Conditions within the Tumor Microenvironment
Inflammatory Cells and Cancer
Matrix Metalloproteinases and Cancer
Text/Ref Books
Cancer biology by Raymond W Ruddon-2009 -4rth Edition
The Biology of Cancer by Robert A Weinberg 2007
Time Schedule
Faculty/Resource Person
Lecturer - Ms Jasmina (MS)