National University of Sciences and Technology
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HCB-817 Cancer Biology
Campus ASAB
Programs PG
Session Fall Semester 2016
Course Title Cancer Biology
Course Code HCB-817
Credit Hours 3
Pre-Requisutes None
Course Objectives
  • Understand cancer statistics and the decommentive epidemiology of cancer;
  • Understand known risk factors and gaps in knowledge for the major cancers;
  • Understand the biology of cancer;
  • Apply methods in the design, conduct, and analysis of cancer research studies;
  • Apply critical thinking in the review of projects and publications in cancer biology;
  • Appreciate the multidisciplinary aspect of cancer including the contributions of basic sciences, clinical medicine and the social sciences to the understanding of cancer biolgy and progression.
Detail Content
  • History &Introduction
    • History of Cancer Detection
    • Stages of Tumor Progression
    • Initiators and Promoters
    • Carcinogens
  • Carcinogens Cancer Causing Substances
    • List of Carcinogens and the Cancers They Cause
    • Environmental Agents and Cancer Development
    • Viruses aand  Bacteria that Cause Cancer
    • Chronic Inflammation and Cancer Development
    • The Two-Stage Model of Cancer Development
    • Cancer Initiation, Promotion and Progression
    • What are Cancer Stem Cells
    • An Introduction to Cancer Treatments
    • Cancer Stem Cells and Treatment
  • Introduction to Cancer Prevention
    • Cancer Detection and Diagnosis
    • Introduction to Cancer by Type
    • Introduction to How Cancer Spreads
  • Introduction to Characteristics of Cancer Cells
    • Changes in Physical Properties of Cancer Cells
    • 1Growth without 'GO' Signals
    • Failure to Respond to 'STOP' Signals
    • Unlimited Number of Cell Divisions
    • Avoidance of Cell Death
    • Angiogenesis
  • Introduction to Metastasis
    • Formation of Metastases
    • Routes of Metastasis
    • Spread of Cancer through the Lymphatic System
    • The Lymphatic System
    • Organ Targeting Anatomic vs Seed & Soil Models
    • The Anatomic Model
    • The Seed and Soil Hypothesis
    • How Metastases Form New Tumors (Colony Formation)
    • Obstacles to Colony Formation
  • Barriers to Metastasis
    • Barriers to Metastatic Cancer Cell Growth
    • Treatments that Target Metastasis (Metastatic Suppressors)
    • Anti-angiogenesis Therapy
  • Introduction to the Tumor-Host Interactions
    • Overview of the Tumor Microenvironment
    • Conditions within the Tumor Microenvironment
    • Inflammatory Cells and Cancer
    • Matrix Metalloproteinases and Cancer
Text/Ref Books
  • Cancer biology by  Raymond W Ruddon-2009 -4rth Edition
  • The Biology of Cancer by Robert A Weinberg  2007
Time Schedule
Faculty/Resource Person Lecturer - Ms Jasmina (MS)